2018, Cilt 27, Sayı 1, Sayfa(lar) 104-107
Rapidly Progressive Renal Failure and Multiple Primary Extranodal Involvement in a Patient with CD5 Positive Diffuse Large B Cell Lymphoma
Şiyar ERDOĞMUŞ1, Seçil SARAL2, Pelin ERTOP2, Tolga AYDIN1, Gizem KUMRU1, Gülşah KAYGUSUZ3, Kenan KEVEN1, Neval DUMAN1, Şule ŞENGÜL1
1Ankara University Faculty of Medicine, Department of Nephrology, Ankara, Turkey
2Ankara University Faculty of Medicine, Department of Dermatology, Ankara, Turkey
3Ankara University Faculty of Medicine, Department of Pathology, Ankara, Turkey
Keywords: CD5 positive diffuse large B cell lymphoma, Primary extranodal lymphoma, Rapidly progressive renal failure, Renal biopsy
Abstract
CD5 positive diffuse large B cell lymphoma is a very rare subtype of diffuse large B cell lymphoma with an aggressive lymphoid neoplasm. Extranodal involvement of lymphoma usually appears secondarily in the setting of disseminated disease, but the disease may originate from various extralymphatic organs. We present a case of primary extranodal lymphoma with coexistence of skin and renal involvement with rapidly progressive renal failure due to lymhpomatous infiltration. Renal biopsy revealed diffuse infiltration of the renal parenchyma by CD20+ atypical lymphoid cells. The patient was treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone. After the chemotherapy regimen, a dramatic improvement in the clinical picture was noticed.
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